This Mississippi Pot Roast is a happy accident turned family favorite—a tender, buttery, tangy pot roast made with just 5 ingredients and minimal prep. Perfect for busy weeknights, it’s a set-it-and-forget-it meal that delivers incredible flavor every time.
Do not add any extra liquid—the roast, butter, and pepperoncini juice create enough. For best results, cook on low for 8 hours. The gravy will solidify when refrigerated but melts back into a silky sauce when reheated. This recipe gets better the next day.
Keywords: Mississippi pot roast, crockpot pot roast, easy pot roast, 5-ingredient pot roast, slow cooker pot roast, chuck roast, pepperoncini pot roast